Discuss the two ways in which drug prevent attachment ofsubstrate on active site of enzyme.
Drugs inhibit the attachment of substrate on active site of enzymes in two different ways :
(i) Drugs compete with the natural substrate for their attachment on the active sites of enzymes. Such drugs are called competitive
inhibitors.
ii) Some drugs do not bind to the enzyme’s active site. These bind to a different site of enzyme which is called allosteric site.This binding of inhibitor at allosteric site changes the shape of active sites in such a way that substrate can not recognise it.
(i) Drugs compete with the natural substrate for their attachment on the active sites of enzymes. Such drugs are called competitive
inhibitors.
ii) Some drugs do not bind to the enzyme’s active site. These bind to a different site of enzyme which is called allosteric site.This binding of inhibitor at allosteric site changes the shape of active sites in such a way that substrate can not recognise it.