Mischief thou art afoot. Take thou what course thou wilt!

pl explian these lines

The literal translation of the lines are: Now let it work.—Mischief, youre working! Take you what course youll!

Antony is very satisfied with the reaction of the people. He had instigated the entire mass of the city of Rome to take revenge and now wanted the course of events and actions to happen on their own. He watches the outraged public to react in a violent way towards the conspirators who killed Julius Caesar.