1.What happens when 1st gen. Merozoites enter new RBCs?
&Similarly what happens when micro-metacryptozoites/2nd gen. Merozoites enter new RBCs?

Dear Student ,

Life cycle of Plasmodium  is digenetic i.e. they complete their life cycle in two hosts
​​​​​ Female Anopheles mosquito is the primary host. The organism which contains sexual phase of the parasite and is regarded as definitive host.
Human contains asexual phase of the parasite and develops symptoms of disease due to the presence of parasite and is termed as secondary host.
When the sporozoites enters the blood it remains active for about half an hour and disappears from the blood circulation.Then it enters into parenchymatous cell of liver through blood circulation by secreting lytic enzymes from the apical cap.Sporozoites in liver cell grow in size and become spherical in shape called schizonts. The nucleus of schizont multiply asexually (multiple fission) and forms thousands of merozoites. These gives pressure to the wall of liver cell and liberated out in the form of cryptozoites.through ruptured liver cell.
The cryptozoites are ready to infect the fresh liver cell where they grow and become schizont. The same process is repeated several times. The liberated merozoites in this phase is called metacryptozoites.Some metacryptozoites are smaller in size called micro metacryptozoites and some are larger in size called macro metacryptozoites.
when the micro metacryptozoites enter into erythrocytes. Single metacryptozoite enters into single RBC and passes through trophozoite stage, signet ring stage, amoeboid stage and schizont stage.The amoeboid feeds completely the component of corpuscles in the form of hemoglobin. During feeding the hemoglobin breakdown into hematin and globin. The globin is absorbed by the cell and hematin is deposited in the form of hemozoin
After some generation of erythrocytic cycle, some of the merozoites invade the new RBC. They grow in size but do not develop into schizonts instead they develop into gametocytes.


Regards.

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