A is the brother of B. B is the daughter of C.C is the son of D and D is the husband of E . How is E related to A?

A is grandson of E.
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E is the grandmother of A.
 A and B are brother-sister so C is the father of both. D is the father of the father of A and B, therefore, D becomes the grandfather of A and B. D is the husband of E, so, E becomes the grandmother.
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