can any body tell me the meaning of fatigue?? Share with your friends Share 0 Smriti Sharma answered this extreme tiredness resulting from mental or physical exertion or illness. 2 View Full Answer Rohit Sahu answered this Fatigue-A feeling of being very tired. 1 Nidhi Jha answered this extreme tiredness resulting from mental or physical exertion or illness. 0 Smriti Sharma answered this hungriness 0 Ashray Gupta answered this big or giving very problem eg: Cancer is a very fatigue disease 1