Can there be any disease caused due to chromosome malfunction ......etc

Dear student 
Yes Some Examples are Down Syndrome trisomy 18 trisomy 13 klinefelter syndrome x y y syndrome Turner syndrome triple x syndrome.
Chromosomal aberration is the abnormality found in any part of normal chromosomal content. Missing, extra or abnormal part of DNA in cell causes aberration. It changes the standard chromosome numbers or can also cause mental as well as physical abnormalities of a person.

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