difference between smooth and rough ER

Dear Student,

The most basic difference between RER and SER is the presence of ribosomes. When ribosomes attach to the surface of an ER, it gives a characteristic rough appearance; hence it is called Rough ER. On the other hand, a smooth ER does not have ribosomes on its surface.

The other major difference between the smooth endoplasmic reticulum and rough endoplasmic reticulum are summarized below:

Rough Endoplasmic Reticulum (RER) Smooth Endoplasmic Reticulum (SER)
It possesses ribosomes attached to its membrane. It does not have ribosomes on its membrane.
Formed of cisternae and a few tubules. Formed of vesicles and tubules.
It participates in the synthesis of enzymes and proteins. Synthesises glycogen, lipids and steroids.
It helps in the formation of lysosomes. Gives rise to Spherosomes/ Oleosomes
It is internal and connected with the nuclear envelope. It is peripheral and may be connected to plasmalemma.
Ribophorins are present and help ribosomes attach to ER Devoid of Ribophorins.
It might develop from the nuclear envelope Develops from Rough Endoplasmic Reticulum.
Provides proteins and lipids for Golgi apparatus. Provides vesicles for cis-face of Golgi apparatus.


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Rough and smooth ER?(endoplasmic reticulum)?differ?in that the?rough ER?has ribosomes on it. ...?Smooth ER?does not have ribosomes and is where steroids are made, which is why there is a lot of?smooth ER?in cells of the the adrenal gland and sex organs which produce steroid hormones such as estrogen and testosterone.
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