Distinguish between (11th std bio) Share with your friends Share 0 Harman answered this The main difference lies between the rer and ser is the presence of ribosomes as ser do not have ribosomes but rer have 0 View Full Answer Nikhat Khan answered this Basic difference between smooth endoplasmic reticulum and rer is that rer contains ribosome and ser doesn't contain...as it name says it's smooth..... 0