#
Estimate and divide

21? 4423

Your question is not clear. however,

If your question is 4423$\xf7$21 then refer to the solution below:-

$4423\xf721\phantom{\rule{0ex}{0ex}}=\frac{4423}{21}\to \frac{4420}{20}\phantom{\rule{0ex}{0ex}}=\frac{4420}{20}\to \frac{442}{2}\phantom{\rule{0ex}{0ex}}=221$

Regards

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