explain enzyme replacement therapy to treat ADA deficiency.mention 2 disadvantages of this procedure.
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Adenosine deaminase (ADA) is an enzyme crucial for immune system. Its deficiency is caused due to the deletion of the gene coding for adenosine deaminase.
Steps involved in gene therapy for ADA deficiency are:
- Lymphocytes isolated from patient’s blood are cultured in-vitro.
- Functional ADA cDNA are then introduced into the cultured lymphocytes.
- These lymphocytes are returned back to the patient’s body.
- It is very costly
- The patient requires repeated infusion of genetically engineered lymphocytes.
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