For what reasons was the Lock and Key hypothesis rejected? What all were the points which it could not explain?

The specific action of an enzyme with a single substrate can be explained using aLock and Keyanalogy first postulated in 1894 by Emil Fischer. In this analogy, the lock is the enzyme and the key is the substrate. Only the correctly sizedkey (substrate) fitsinto thekey hole (active site)of thelock (enzyme).

Smaller keys, larger keys, or incorrectly positioned teeth on keys (incorrectly shaped or sized substrate molecules) do not fit into the lock (enzyme). Only the correctly shaped key opens a particular lock. This is illustrated in graphic on the left.

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A hypothesis will be rejected if it fails the necessary testing required for it to become a scientific theory.

The lock is the equivalent to that of an enzyme while the key is portrayed as the substrate.Like an enzyme, the lock can be reused many times as it remains chemically unchanged at the end of the reaction. Also, the fact that reactions occur only at the active site, or binding site, is showed as the key only being able to open the lock only at the keyhole, not anywhere else.The hypothesis also shows the fact that enzymes can only catalyse a specific substrate, showed as the lock, only being able to open with a specific key.Firstly,the substrate will enter the active side of the enzyme.then,the enzyme will change it shape slightly as the substrate binds.During this time,the substrate will be broken down.After that,the product will leave the active sides of the enzyme.

The significance test is the process used, by researchers, to determine whether the null hypothesis is rejected, in favor of the alternative research hypothesis, or not.

The test involves comparing the observed values with theorized values. The tests establish whether there is a relationship between thevariables, or whether pure chance could produce the observed results.

In everyday language, 'significance' means that something is extremely important. For example, an office manager might state that a new computer system has 'significantly' improved the efficiency of their staff. The term is used in a loose context, a belief that the new system is an instrumental factor in improving workflow

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