How ANF opposess the regulation by RAAS???
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ANF (Atrial Natriuretic Factor) is a hormonal substance produced by the right atrium of the heart in most mammals. It is an important component of circulatory regulation.
ANF helps in relaxation of glomerular arterioles and mesangial cells and simultaneously constricting efferent arterioles. As a result of which there occurs rise in capillary hydrostatic pressure, which causes loss of salt and water through urine.
When there is an increase in the blood flow (volume) and pressure to the atria of the heart, the release of ANF (atrial natriuretic factor) is caused. Its release causes vasodilation and a decrease in the blood pressure. Thus, it works oppositely to the renin-angiotensin mechanism by inhibiting the release of renin.
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