How blood clots?Explain. Thrombocytes are essential for the coagulation of blood.Comment on it. ( 3 mark question).
Clot formation occurs in three steps.
- Thromboplastin helps in the formation of prothrombinase enzyme. This enzyme inactivates heparin and it also converts the inactive prothrombin into active thrombin. Calcium ions helps for these changes.
- Thrombin acts as a proteolytic enzyme to separate two peptides from the soluble fibrinogen molecule to form insoluble fibrin.
- The fibrin polymerizes to form long, sticky fibres. The fibrin threads form a fine network over the wound and tap blood cells to form a crust – the CLOT.
Thromboplastin is a lipoprotein plays a major role in blood clotting.