How does hershey and chase prove that dna is a genetic material

The experiment began with the culturing of viruses in two types of medium. One set of viruses (A) was cultured in a medium of radioactive phosphorus whereas another set (B) was cultured in a medium of radioactive sulfur. They observed that the first set of viruses (A) consisted of radioactive DNA but not radioactive proteins. This is because DNA is a phosphorus-based compound while protein is not. The latter set of viruses (B) consisted of radioactive protein but not radioactive DNA.

The host for infection was E.coli bacteria. The viruses were allowed to infect bacteria by removing the viral coats through a number of blending and centrifugation.

Observation:  E.coli bacteria which were infected by radioactive DNA viruses (A) were radioactive but the ones that were infected by radioactive protein viruses (B) were non-radioactive.

Conclusion: Resultant radioactive and non-radioactive bacteria infer that the viruses that had radioactive DNA transferred their DNA to the bacteria but viruses that had radioactive protein didn’t get transferred to the bacteria. Hence, DNA is the genetic material and not the protein.

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