How is it point mutation in the second sub division that is in 3 a) ii)
Dear Student,
The original sequence is :
3' --- CAT CAT AGA TGA AAC --- 5'
1) 3' ---- CAT CAT AGA TGA ATC --- 5'
In this case, the Adenine (A) is replaced with Thymine (T), this type of point mutation involving one base change is referred to as Transversion (as Adenine is Purine while Thymine is Pyrimidine)
2) 3' ---- CAT 'C'ATA GAT GAA AC --- 5'
In this case, the Cytosine (C) got deleted in the process of the replication, this type of point mutation involving one base change (missing) is referred to as Deletion (as one base has been deleted/or is missing) thus, it leads to change in the frame for the translation process. Therefore, it is also called as 'Frame-shift mutation'.
Regards
The original sequence is :
3' --- CAT CAT AGA TGA AAC --- 5'
1) 3' ---- CAT CAT AGA TGA ATC --- 5'
In this case, the Adenine (A) is replaced with Thymine (T), this type of point mutation involving one base change is referred to as Transversion (as Adenine is Purine while Thymine is Pyrimidine)
2) 3' ---- CAT 'C'ATA GAT GAA AC --- 5'
In this case, the Cytosine (C) got deleted in the process of the replication, this type of point mutation involving one base change (missing) is referred to as Deletion (as one base has been deleted/or is missing) thus, it leads to change in the frame for the translation process. Therefore, it is also called as 'Frame-shift mutation'.
Regards