how to make investigatory project of biology on vaccination

with your hands of course!

Make a cover page related to vaccination make sure it has your name class and topic mentioned.
next write acknowledgment 
certificate from school
index 
introduction should include some research and background information which you understand and can be answered during viva
then the experiment done in your school on the topic
ask you teachers for some more help
you can search for example of the projects on slideshare or scribd. 
All the best!