if a norm man marries women who us carrier of sickle cell anemia,what is probability of having carrier children
Sickle cell anemia is an autosomal recessive disease in which RBC shape become sickle like. In this question when normal man (HbAHbA) marries a woman who is carrier of sickle cell anemia(HbAHbS) then their progeny will be-
Female Male
HbSHbA X HbAHbA
offspring will be
HbSHbA HbSHbA HbAHbA HbAHbA
(male) (female) (male) (female)
i.e. half the offspring is normal(HbAHbA) and half is carrier(HbAHbS)
so, probability of having carrier children to this disease is 50%
Female Male
HbSHbA X HbAHbA
offspring will be
HbSHbA HbSHbA HbAHbA HbAHbA
(male) (female) (male) (female)
i.e. half the offspring is normal(HbAHbA) and half is carrier(HbAHbS)
so, probability of having carrier children to this disease is 50%