Imagine a discovery of a new toxin that blocks renal tubule reabsorption but does not affect filtration. Predict short term effects of this toxin.
The toxin will affect the tubular reabsorption hence all the useful materials like mineral ions, glucose, amino acids etc will also be excreted from the body. Reabsorption of water will also be affected and as a result very dilute urine will be produced. The affected person's health will degrade because he will suffer excessive loss of water and other essential substances.