mention the role of calcium ion and thromboplastin in coagulation of blood

Dear Student,

Blood clotting is a very complex process which results in the repair if injured blood vessels. It involves end number of factors, platelets and dozens of proteins. The activation of platelets trigger a complex series of reactions that produces a clot. Calcium ions are involved in various steps in the process of blood clotting. There major role is in the activation of the platelets, prothrombin and other factors involved in the process.
 

Blood clotting helps for the excessive loss of blood from an injury caused to the body. It is initiated by platelets. Thromboplastin is a lipoprotein plays a major role in blood clotting.

Clot formation occurs in three steps.

  1. Thromboplastin helps in the formation of prothrombinase enzyme. This enzyme inactivates heparin and it also converts the inactive prothrombin into active thrombin. Calcium ions helps for these changes.
  2. Thrombin acts as a proteolytic enzyme to separate two peptides from the soluble fibrinogen molecule to form insoluble fibrin.
  3. The fibrin polymerizes to form long, sticky fibres. The fibrin threads form a fine network over the wound and tap blood cells to form a crust – the CLOT.

Clot is formed in about 2 – 8 minutes and seals the wound and stop bleeding.

Regards

 

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