Pancreas Produces pancreatic juice of water, enzymes, electrolytes. Clusters of acinar cells produce enzymes. Epithelial cells release HCO3- that neutralizes acid chime and provides optimal environment for intestinal and pancreatic enzymes.Secretin released from enteroendocrine cells of duodenum stimulates release of bicarbonate-rich pancreatic juice to neutralize HCl.CCK is released in response to entry of fats and protein into duodenum. Stimulates release of enzyme-rich pancreatic juice.
