the pH of blood stream is maintained by a proper balance of H2CO3 and NaHCO3 concentration. what volume of 5M NaHCO3 solution should be mixed in 10ml sample of blood which is 2M in H2CO3 in order to maintain the pH of 7.4? Ka of H2CO3 = 7.8*10^-7

Hi,Let V be the required bolume of 5 M NaHCO3 solution. Total volume of the system become V+ 10ml. In the solution,HCO3- = 5M V V+ 10HCO3 = 2M 10 V+ 10Using the expression pH = pKa° + logHCO3-HCO37.4 = -log7.8 ×10-7 + log  5MV2M10 ml =6.106 + log 14 + logV/mllogV/ml= 7.4-6.108 + 0.062 = 1.894V = 78.34 mlRegards

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