There are no tRNAs for stop codon. what does this mean?
Polyeptide synthesis is terminated when a nonsense codon of mRNA reaches the A-site on the larger subunit of ribosome. There are three nonsense codons- UAA, UAG and UGA. These codons are not recognised by any of the tRNAs. This brings the termination of polypeptide synthesis as no more aminoacyl tRNA reaches the A site. The P site tRNA is hydrolysed and the completed polypeptide is released in the presence of GTP dependent release factor.