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What is denaturation? How does it happen? What are it's effects?

Dear Student!

@ponmanoharan: I would like to add one more thing to the answer provided by rishita, once the denaturating conditions are removed the protein regains its secondary structure and that is called renaturation.

@Rishita: Very good! Keep up the good work.

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Denaturation of proteins involves the disruption and possible destruction of both the secondary and tertiary structures. Since denaturation reactions are not strong enough to break the peptide bonds, the primary structure (sequence of amino acids) remains the same after a denaturation process. Denaturation disrupts the normal alpha-helix and beta sheets in a protein and uncoils it into a random shape.

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Thanks a lot.

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