What is ornithine cycle?

Dear student,

Ornithine cycle (urea cycle) is involved in conversion of harmful and toxic catabolites of proteins into urea. It occurs majorly in liver of ureotelic organisms. Ammonia combines with carbon dioxide and ATP to form urea by this cycle

 It consist of five reactions- two occur in the mitochondria and remaining three in cytosol. In the last step Arginase enzyme is involved in the conversion of arginine into ornithine.

Overall reaction
2 NH3 + CO2 + 3 ATP + H
2O → urea + 2 ADP + 4 Pi + AMP
 

Regards.

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