What is oxidative decarboxylation? What happens to pyruvate immediately after the glycolysis during aerobic respiration? Name the enzyme involved in the reaction.

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 Dear Student,

Oxidative Decarboxylation reactions are oxidation reactions which involves the removal of Carboxylate group to form Carbon dioxide.

Pyruvate is formed after glycolysis. It then travels to mitochondria to undergo decarboxylation. Before entering the Citric acid cycle, Pyruvate is prepared by decarboxylation reaction to release a CO2 and a pair of electrons that will be used ultimately by the Electron transport Chain. This reaction is mediated by Pyruvate Dehydrogenase Complex.

In Citric acid cycle, this reaction takes place three times to generate CO2 , also reducing NADto NADH.

1. Pyruvate is converted to acetyl Co-A by Pyruvate dehydrogenase

      Pyruvate + Co-A + NAD+ Pyruvate dehydrogenase complex   Acetyl Co-A + CO+ NADH

2. Isocitrate is converted to α-Ketoglutarate by the enzyme Isocitrate dehydrogenase also releasing CO2 and transfer of electrons to NAD‚Äč+  from NADH.

3. α-Ketoglutarate is converted to Succinyl Co-A by the enzyme α-Ketoglutarate dehydrogenase also forming CO2 and transfer of electrons from NADH



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