What is the difference between: biosphere reserves and biodiversity hotspots

Biosphere reserve Biodiversity hotspots
Biosphere reserve refers to an area that is set aside for the conservation of the resources of the biosphere and for the improvement of the relationship between man and the environment.  Biodiversity hotspot is a biogeographic region that is both a significant reservoir of biodiversity and is threatened with destruction.
These are man-made. These are present naturally.

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