Which factor in tissues favours the formation of HCO_​3 ^- and H⁺ ions in the blood?

Dear student,

Carbonic anhydrase is the zinc containing enzyme that catalyzes the interconversion of CO₂ with HCO₃^- and H⁺.
The carbon dioxide formed as a result of tissue metabolism combines with water to form carbonic acid in the following reaction :
                   CO₂ + H₂O ---------> H₂CO₃ (Reversible reaction)
This readily dissociates to form hydrogen ion and bicarbonate ions as follows :
                    H₂CO₃ --------------> H ⁺ + HCO_​3  (Reversible reaction)​

Regards.