Why is bone marrow transplantation not a permanent cure for ada deficiency? ???? Plz ans as soon as possible. Plzzzzzzzz

Dear student,
Please find below the solution to the asked query

Adenosine deaminase (ADA) is an enzyme crucial for immune system. Its deficiency is caused due to the deletion of the gene coding for adenosine deaminase.

The transplantation of bone marrow is not the permanent cure for ADA deficiency because this method may require repeated application and it is difficult to find the exact match. Also, it is associated with complications like infections, graft versus host disease and lack of engraftment. 

 A permanent cure for ADA deficiency is to introduce genes isolated from marrow cells that produce ADA into cells of patient at early embryonic stages.

Hope this information will clear your doubts about the ADA deficiency.
If you have any more doubts just ask here on the forum and our experts will try to help you out as soon as possible.

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