What is Corey-House alkane synthesis

Corey –House synthesis involves the formation of alkanes through following steps:

1) Reaction of alkyl halide with lithium, in dry ether to form alkyl lithium:

 

2) Reaction of alkyl lithium with CuI to form dialkyllithiumcuparate known as Gilman reagent.

 

3) Reaction of dialkyllithiumcuparate with alkyl halide to give alkane:

 

 

This method is mainly used to prepare alkanes of R-R’ type.

 

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