What is Corey-House alkane synthesis
Corey –House synthesis involves the formation of alkanes through following steps:
1) Reaction of alkyl halide with lithium, in dry ether to form alkyl lithium:
2) Reaction of alkyl lithium with CuI to form dialkyllithiumcuparate known as Gilman reagent.
3) Reaction of dialkyllithiumcuparate with alkyl halide to give alkane:
This method is mainly used to prepare alkanes of R-R’ type.