4 differences between organ specific and tissue specific manifestation.

When a microbe infects the specific organ of an individual in a particular type of disease, it is termed as organ specific manifestation. For example, in tuberculosis the microbe infects the specific organ i.e. lungs of an individual.

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When a microbe infects the tissues of the body of an individual in a particular type of disease, it is termed as tissue specific manifestation. For example, in HIV the virus infects the tissue and cells of the organism making decreasing his/her immunity.