Antibiotics kill some of the symbiotic microbes in the caecum so samples of those microbes are stored in the appendix ...WHY DOESNT ANTIBIOTIC ENTER THE APPENDIX??
Dear Student
First of all to treat appendix antibiotics are not the exact treatment or prior treatment , generally to treat appendix we have to go surgical procedure a research was conducted by Vons and colleagues based on a multicentre, open-label, non-inferiority, randomized controlled trial in which they comparing results of treatment with amoxicillin-clavulanic acid with emergency appendectomy in patient with uncomplicated acute appendicitis. Patients who are receiving amoxicillin-clavulanic acid because of its efficacy in treating uncomplicated sigmoiditis . Antibiotic therapy was given through injections to patients with nausea or vomiting, and orally to all others. After discharge, patients continued amoxicillin-clavulanic acid at the same dose for eight days and were seen on Day 8; if patients had a sustained high white blood cell (WBC) count or elevated C-reactive protein (CRP), antibiotics were continued for another 8 days with surgical intervention on Day Fifteen if laboratory abnormalities persisted. The first endpoint was occurrence of peritonitis within thirty days of initial treatment and authors used a non-inferior margin of ten percent Diagnosis of peritonitis amongst patients randomized to receive antibiotic therapy occurred when a complicated appendicitis was identified through appendectomy. Patients randomized to antibiotic therapy had significantly higher rates of thirty day post-intervention peritonitis compared with the appendectomy group (eight% versus two%, treatment difference 5.8; 95 percent CI, 0.3–12.1). Of the 120 patients randomized to antibiotic therapy, thirty nine underwent appendectomy due to acute appendicitis within one-year follow up of the fourteen procedures that occurred within 30 days, nine were due to complicated appendicitis. Authors finally concluded that antibiotic therapy with amoxicillin-clavulanic acid was not non-inferior to emergency appendectomy for the treatment of acute uncomplicated appendicitis.
So ths research proved that Antibiotic are not the primary way to treat appendicitis, and antibiotics can not enter or target directly in case of appendix.
Regards
First of all to treat appendix antibiotics are not the exact treatment or prior treatment , generally to treat appendix we have to go surgical procedure a research was conducted by Vons and colleagues based on a multicentre, open-label, non-inferiority, randomized controlled trial in which they comparing results of treatment with amoxicillin-clavulanic acid with emergency appendectomy in patient with uncomplicated acute appendicitis. Patients who are receiving amoxicillin-clavulanic acid because of its efficacy in treating uncomplicated sigmoiditis . Antibiotic therapy was given through injections to patients with nausea or vomiting, and orally to all others. After discharge, patients continued amoxicillin-clavulanic acid at the same dose for eight days and were seen on Day 8; if patients had a sustained high white blood cell (WBC) count or elevated C-reactive protein (CRP), antibiotics were continued for another 8 days with surgical intervention on Day Fifteen if laboratory abnormalities persisted. The first endpoint was occurrence of peritonitis within thirty days of initial treatment and authors used a non-inferior margin of ten percent Diagnosis of peritonitis amongst patients randomized to receive antibiotic therapy occurred when a complicated appendicitis was identified through appendectomy. Patients randomized to antibiotic therapy had significantly higher rates of thirty day post-intervention peritonitis compared with the appendectomy group (eight% versus two%, treatment difference 5.8; 95 percent CI, 0.3–12.1). Of the 120 patients randomized to antibiotic therapy, thirty nine underwent appendectomy due to acute appendicitis within one-year follow up of the fourteen procedures that occurred within 30 days, nine were due to complicated appendicitis. Authors finally concluded that antibiotic therapy with amoxicillin-clavulanic acid was not non-inferior to emergency appendectomy for the treatment of acute uncomplicated appendicitis.
So ths research proved that Antibiotic are not the primary way to treat appendicitis, and antibiotics can not enter or target directly in case of appendix.
Regards