can plz explain the life cycle of plasmodium...?
Life cycle of plasmodium-
* Plasmodium requires two hosts to complete its life cycle. * When female Anopheles mosquito bites a healthy human being, it releases Plasmodium, which lives in its body as sporozoite (infectious form). * The parasites multiply (asexual reproduction) in the liver cells and finally burst the liver cells. Sporozoites are released in blood. * Parasites enter RBCs and further multiply (asexual reproduction) here and finally burst RBCs also. * Bursting of RBCs is accompanied by release of a toxic substance called haemozoin (associated with fever and chills). * In the RBCs, only sporozoites change into gametocytes (sexual stage). Gametocytes multiply. * When the diseased person is bitten by a female Anopheles mosquito, gametocytes are introduced into the mosquito. * Gametocytes fertilise and develop inside the intestine of mosquito to form sporozoites. * Sporozoites are stored in the salivary glands of mosquito and are released into the healthy person who is bitten by this mosquito.