Differentiate between unicellular and multicellular organisms

uni:contains only one cell.Eg:amoeba and chlamydomonas.
multi:contains million of cells.Eg:plants and animals
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The main difference between unicellular and multicellular is some organisms are made-up of single cell termed as unicellular while multicellular are made-up of two or more cells.Single celled organism is called unicellular organism. Unicellular organisms have greater surface area to volume ratio.
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Please refer above for a few differences. You can also find a table in the fundamental unit of life concepts of meritnation. 
Regards
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Unicellular Organisms Multicellular Organisms
Unicellular organisms are composed of a single cell Multicellular organisms are composed of more than one cell
Simple body organization Complex body organization
A single cell carries out all necessary life processes Multiple cells perform different functions
The total cell body is exposed to the environment Only the outer cells are exposed to the environment
Division of labour is at the organelle level Division of labour is at cellular, tissue, organs and organ system level
Includes both eukaryotes and prokaryotes Includes only eukaryotes
A lifespan of a unicellular organism is usually short Multicellular organisms have a comparatively longer lifespan
Injury to the cell leads to the death of the organism Injury to a cell does not cause the death of the multicellular organism
Asexual reproduction is predominant, however, sexual reproduction is also seen (conjugation) Reproduction happens sexually as well as asexually
Cell differentiation is absent Cell differentiation is present
They can be autotrophs or heterotrophs They include both autotrophs and heterotrophs
They are microscopic in nature Most are macroscopic in nature
Bacteria, amoeba, paramecium and yeast are examples of unicellular organisms Humans, animals, plants, birds and insects, are examples of multicellular organisms
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