Initial clue about the genetic / chromosomal mechanism of sex-determination can be traced back to some of the experiments carried out in
a)Human beings

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​Please find below the solution to the asked query                

A number of insects (e.g. Drosophila) were used to show genetic mechanism of sex determination and the cytological observations in them led to the development of this mechanism. These studies were done by Henking.So, the initial clue about chromosomal mechanism of sex determination came from the experiments carried out in insects.

Hence, option (c) is correct. 
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