Why it is necessary to DNA to get bind with different types of histones ?
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Please find below the solution to the asked query
DNA is negatively charged. So, to stabilize the system some positively charged (basic) protein molecules called histones are bound to it. There is large amount of DNA in our cells which creates a packaging problem. So, in order to maintain a high degree of organisation, DNA is folded. DNA helix combines with a group of eight histone molecules called histone octamer to form a structure called nucleosome. DNA is negatively charged due to the negatively charged phosphates in the backbone. When positively charged histones bind to DNA, all its negative charge would be counter balanced. Histones contain high amounts of two positively charged amino acids: lysine and arginine. Nucleosome have 147 base pairs of DNA wound over histones.
There are five types of histone proteins H1 , H2A , H2B ,H3 and H4. Four of these occur in pairs and hence produce histone octamer forming the core of nucleosome. Hence, DNA binds with different types of histone proteins or to a histone octamer.
Hope this information will clear your doubts about the topic.
Please find below the solution to the asked query
DNA is negatively charged. So, to stabilize the system some positively charged (basic) protein molecules called histones are bound to it. There is large amount of DNA in our cells which creates a packaging problem. So, in order to maintain a high degree of organisation, DNA is folded. DNA helix combines with a group of eight histone molecules called histone octamer to form a structure called nucleosome. DNA is negatively charged due to the negatively charged phosphates in the backbone. When positively charged histones bind to DNA, all its negative charge would be counter balanced. Histones contain high amounts of two positively charged amino acids: lysine and arginine. Nucleosome have 147 base pairs of DNA wound over histones.
There are five types of histone proteins H1 , H2A , H2B ,H3 and H4. Four of these occur in pairs and hence produce histone octamer forming the core of nucleosome. Hence, DNA binds with different types of histone proteins or to a histone octamer.
Hope this information will clear your doubts about the topic.
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