What is the limitations of corey house synthesis?
The Corey–House synthesis is a method of preparation of alkane using lithium dialkyl cuprate and alkyl halide.
R2CuLi + R'-X → R-R' + RCu + LiX
Limitation:
The reaction will be successful only if the alkyl group in alkyl halide (R'-X) is primary (or secondary) in nature.
R2CuLi + R'-X → R-R' + RCu + LiX
Limitation:
The reaction will be successful only if the alkyl group in alkyl halide (R'-X) is primary (or secondary) in nature.